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Chlamydia Damages Sperm, Experts Found

 

chlamydia transmission , which is often known as the silent disease because it has few symptoms, reduces a man's ability to produce children, they found.




 
Research has found Chlamydia damages sperm
 The disease, which is still on the rise in the UK, is more well known for making women infertile if left untreated.




But now researchers, led by Dr Jose Fernandez from Canalejo University Hospital in La Coruna, Spain, have discovered how chlamydia also affects men.




They looked at the damaged sperm of 143 men from infertile couples and compared it with sperm from 50 fertile men.




 




The infertile men had chlamydia and another common urinary tract infection called Mycoplasma.




The level of damage - or DNA fragmentation - in the infertile men's sperm was more than three times higher than in healthy men.




The concentration of their sperm, its ability to swim quickly and defects in the shape of it were also poor when compared with the healthy volunteers.




The experts then treated 95 of the infertile men with antibiotics and found their DNA sperm damage improved an average of 36% after four months.




During that period, 13% of the couples got pregnant and, after the treatment was finished, 86% got pregnant.




The findings were released today at the American Society for Reproductive Medicine conference in Washington DC.




Figures published in July by the Health Protection Agency showed a 4% rise in chlamydia between 2005 and 2006, from 109,418 cases to 113,585.




Experts have been particularly concerned about rates of chlamydia among young people, with the NHS launching a national screening programme.




In 2006/07, 115,073 women under 25 were screened but experts are urging more young men to get tested, with only 31,126 screened during the same period.




Dr Allan Pacey, senior lecturer in andrology at the University of Sheffield and Secretary of the British Fertility Society, said more needed to be done to target the younger generation.




He said: "The message is that we might think of chlamydia as a disease that damages female fertility, but we need to think again.




"It does damage female fertility, but it appears to damage male fertility too.




"The thing that drives most men to sexual health clinics is symptoms, and chlamydia is often symptom-free.




"Chlamydia is getting out of control. We have got to encourage men as well as women to go for screening, but men are more reluctant to do this if they don't have symptoms.




"It is the 18 to 25 age group that is of most concern. There should be a page on Facebook you can log onto and sort screening out."




Dr Fernandez said more research was needed to follow up his study.




And he added: "We've developed a new technique that allows us to look at the extent of DNA fragmentation in sperm cells using a microscope. "The purpose of our work was to analyse if there's an increase in fragmentation of DNA with infection.




"It was found after four months of treatment there was a significant decrease in DNA damage that could improve pregnancy rates in these couples.




"Fertility clinics should check for these infections."


PR

Chlamydia Infection May Pave Way For Cancer Via DNA Damage

std symptoms can cause DNA damage that may increase the risk of later developing cancer, a new study suggests.


In the study, human cells growing in lab dishes that were infected with chlamydia were more likely to have DNA damage compared to cells not infected with chlamydia. What's more, this DNA damage was not always repaired properly by the cell, increasing the chances of genetic mutations.


Normally, cells with such DNA damage would activate a process that kills the cells, so that the cell does not turn cancerous. But in the study, the cells with DNA damage overrode this mechanism, and continued to divide. The continued division of cells with DNA mutations could eventually lead to cancer, the researchers said.


Earlier studies found an association between chlamydia infections and an increased risk of cervical and ovarian cancer in people, but such studies cannot prove cause and effect. The new study provides a biological explanation for how chlamydia could increase the risk of cancer.


However, because the study was conducted in cells in a lab dish, more research is needed to show the same thing occurs in people.


The new study, conducted by researchers at the Max Planck Institute for Infection Biology in Berlin, was published June 12 in the journal Cell Host & Microbe.


Chlamydia is a sexually transmitted disease caused by the bacteria Chlamydia trachomatis. Most infected people have no symptoms, according to the Centers for Disease Control and Prevention. However, untreated infections can damage the reproductive tract in women, and cause infertility. Complications from untreated infections are rare in men, but the condition can cause a burning sensation when urinating, and very rarely, prevent a man from fathering children, the CDC says.


Chlamydia Risk Revealed in Latest STIs Report

Chlamydia Cure was once again the most common sexually transmitted infection (STI) as Rushmoor was revealed to have the highest rate of infections across the Hampshire-Surrey border.


The data from Public Health England showed that the STI rate per 100,000 people in Rushmoor was 796 – marginally higher than in the borough of Guildford where the rate was 794 per 100,000 people.


This compared with a Hampshire average of 583 STIs in every 100,000 people and 545 in Surrey.


Last year, 751 acute STIs were diagnosed in Rushmoor, with 330 of these being chlamydia - a common bacterial infection that often has no symptoms in women but can cause blindness.


This means there were 20 more new chlamydia cases than in 2011.


Cases of the infection fell by 6% to 184 in Hart, by 15% to 293 in Guildford, by 30% to 153 in Surrey Heath and by 13% to 160 in Waverley.


The overall number of all STIs diagnosed in these areas was 524 in Hart, 1,093 in Guildford, 504 in Surrey Heath and 556 in Waverley.


Syphilis cases increased most dramatically in Hart, from zero in 2011 to three in 2012, and in Guildford, where there were seven diagnoses last year compared to four in 2011 and one the year before.


Despite this it remained by far the least common infection in the data.


Cases of gonorrhoea and herpes were more frequent in 2012 than at any point in the past four years in Guildford, Surrey Heath and Waverley, but cases fell in Hart.


Rushmoor was the only borough where diagnoses of genital warts increased – rising from 160 to 169.


The increases in some STIs has prompted a warning from Hampshire County Council to people to take more care with their sexual health.


Councillor Liz Fairhurst, executive lead member for health and wellbeing, said: “Left untreated, sexually transmitted infections can lead to a range of complications including ectopic pregnancy, infertility, disability, cancer and premature death.


"As part of our new public health responsibilities, Hampshire County Council already commissions a range of programmes and services delivered in a variety of community settings that support people to develop and maintain good sexual health.


"Getting screened for HIV and STIs can lead to early diagnosis and treatment, as often these infections have no symptoms.


"In addition, reducing the number of sexual partners and avoiding overlapping sexual relationships can reduce the risk of being infected with an STI."


The Public Health England figures also showed that those aged between 15 and 24 were most at risk from chlamydia.


There were 226 diagnoses in this age group last year in Rushmoor – lower than the 248 in 2011 – whereas there were 103 cases in those older than 25 last year.

Chlamydia Infections May Increase Risk Of Gynecological Cance

Persistent infection by Chlamydia Treatment may increase the risk of cancer via damage to the DNA, according to a report published in the journal Cell Host & Damage. In addition to mutating host cell DNA, the disease also inhibits cellular mechanisms intended to repair the damage.


Researchers at the Max Planck Institute for Infection Biology in Berlin grew human cells in a lab, then infecting them with chlamydia. The group of cells infected were more likely to show damage than their uninfected counterparts.


The researchers also found that the damage done to the cells is similar to the damage done by cancer. Cells that did not simply die when infected went on to reproduce others imprinted with the same DNA damage.


In 2009, the Center For Disease Control reported that 84,000 women were diagnosed with a gynecologic cancer. It's unclear how many may have been linked with a chlamydia infection, but doctors urge women - who can host the disease for long periods of time with no symptoms - to get screened for it.

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